DIFFICULTIES IN MANAGING METHEMOGLOBINEMIA

Difficulties In Managing Methemoglobinemia

Acute poisoning with nitrobenzene causing significant methemoglobinemia is a rare yet life-threatening emergen-cy.A 20-year-old, female presented to Emergency in altered sensorium with a history of consumption of a bioor-ganic formulation.On examination she was cyanosed restless and THONGS agitated with SpO2 of 70% on room air.Blood samples drawn f

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Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons

Abstract The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects.We previously showed that TIMP-1 reduces neurite outgrowth in mouse cortical neurons and that this cytokine-like effect depends on TIMP-1 endocytosis mediated by the low-density lipoprotein receptor-r

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